The Design of my Course, Cancer Prevention 2019, Module_2, Submission Time: 20190401T0438,

by K Moses

Here is an example from my completion of a ‘certification course’ for teaching online, it was required and pitched as being for "online" proficiency … I describe the course like this: I found the Course (Crafted by George Andreadis and Ian August, Online Learning & Services, St. John’s University ) excellent guidance and an opportunity to review my teaching practice. This submission included the design for my Course, Cancer Therapeutics, now titled Cancer Prevention, 9th of July 2019.

The shortened URL for this page, http://bit.ly/2UcCMLZ,
My approach to ‘Module 2: Blooms Taxonomy Assignment’ was to use it to think about the overall design of a Course by using the construction of Outcome-Based Learning Objectives I am shortening this language to Learning Outcomes which reaches the same meaning and immediately conveys where we are on this,
Below I produce three Learning Outcomes that criss-cross a Course called Cancer Therapeutics or maybe Cancer Therapy 2019,* the Outcomes can be described as the three eras of the Course. I would likely incorporate these in any promotional material for the Course. I found focusing on the term ‘outcomes’ helped me towards a more active notion of learning and collaborative scaffolding to learn.
* I have decided to go for a more easily digestible name, Cancer Therapeutics, in the series of courses I have been teaching it will fit into this structure, Human Health: Cancer Therapeutics,
I interpreted it would be possible to make measurable each of the sub-outcomes, e.g., a sub-outcome - List and describe the Hallmarks of Cancer, … either the Class member has or has not accomplished the sub-outcome or has some variation on the sub-outcome to share with their colleagues. Measurable outcomes can be used as the basis for a grading assessment which I would make flexible to how the members of the class wished to re-craft outcomes for their particular needs. In the Course, I would make the construction of outcomes a collaborative effort, welcoming class member input. ‘Measurable' would work like this, based on the first Learning Outcome above, if a member is able to list and describe all Hallmarks they earn 100% for the assignment, if they can do some lesser number, ok we have a scaling … again incorporating efforts towards evaluation design on the front end will aid us in the future assessment of our accomplishments with the Curriculum and any review of the Curriculum. Measurable appears to require an adaptable rubric template available to collaboration at the beginning of the Course and for every assignment; I am / we are considering this, the current version of our Adaptable Rubric, http://bit.ly/Adabptable_Rubric, 20190412,
The End of the Course has the major sub-outcome of crafting a Literature Review to support our proposed interventions in Cancers Progress;
With respect to addressing our current Online Teaching Assignment: [A.] ‘[] you will create a variety of measurable learning objectives. [B.] Take a learning objective from the course you are developing and design learning objectives for each level of [B]looms [T]axonomy[,]’
For A., I put forward,
Cancer Therapeutics: Learning Outcomes
  • Upon completion of our Classes 1 - 6 on the Hallmarks of Cancer students will be able to:
    • List and describe the Hallmarks of Cancer,
      • Dear Class, We will present our work as individual and as collaborative submissions for both our written work and presentations to our fellow Class members,

    • Describe the dynamic relationship between the Hallmarks of Cancer,

    • Illustrate the diversity of the dynamic relationship between the Hallmarks in different types of Cancer,

  • Foundational Reference for the above section of the Course: Floor et al, ‘Hallmarks of Cancer: Of All Cancer Cells, All the Time?’ Trends in Molecular Medicine 18, no. 9 (September 2012): 509–15. https://doi.org/10.1016/j.molmed.2012.06.005. … Please review the Abstract for this description "We consider cancer as an evolving, dynamic, and heterogeneous system, explaining, at least in part, the difficulty of treating cancer and supporting the use of simultaneous, multitarget therapies."
  • Upon completion of the Classes (7 - 12), we will be able to illustrate and explain the diversity of the dynamic relationship between the Hallmarks of Cancer in different types of Cancer; we will use our explanations to analyse the:
    • The variable evolving nature of Cancers,
    • The heterogeneous nature Cancer,
    • We will use our analysis to explain the difficulties of treating Cancer, and examine strategies focused on targeting the Hallmarks,

  • Foundational References for guiding the above section of the Course are:
    • The patent application, ‘PEPTIDES CAPABLE OF REACTIVATING p53 MUTANTS,’ U.S. Patent Application No. 15/796811 (Filed: 29 October 2017), Publication No. 20180057533 (2019-05-08, Application status is Pending), https://patents.google.com/patent/US20180057533A1/en, Applicants: Moshe Oren et al. … consider proposing that the therapeutic peptides disclosed in the invention are changing the very local molecular environment of key mutant proteins in Cancer, mutp53,
      • Abstract: ‘The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and isolation of such peptides, in a precise, cost and time effective manner. In particular, there are provided mutant p53 reactivating peptides that can restore the native wild type p53 folding, and hence the tumor suppressor activity, to the mutant p53 protein. Such peptides are useful for treating various conditions and diseases in which p53 is mutated.’
    • Schulz-Heddergott, Ramona and Ute M. Moll. "Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target." Cancers (Basel)., vol. 10, no. 6, June 2018, doi:10.3390/cancers10060188. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025530/ and Citations to Schulz-Heddergott and Moll, 2018 are here, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025530/citedby/
  • During completion of the Classes (13 - 18), we will be designing potential therapeutic strategies, which includes,
    • Reviewing the current status of knowledge on the dynamics of and therapeutic strategies for Lung and Breast Cancer,

    • Crafting a Literature Review to support our proposed interventions in Cancer Development,

    • Crafting and doing a presentation to our fellow Class members on our review and proposed interventions.
For B.: Take a learning objective from the course you are developing and design learning objectives for each level of Bloom’s Taxonomy,
  • Upon completion of the Classes (1 - 6) on the Hallmarks of Cancer students will be able to:
    • List and describe the Hallmarks of Cancer,
      • Describe the dynamic relationship between the Hallmarks of Cancer,
        • Illustrate the diversity of the dynamic relationship between Hallmarks in different types of Cancer,

        • Bloom’s Taxonomy: (Here, I would focus on action verbs associated with each level of a revised Bloom’s Taxonomy for crafting learning outcomes, assignments, and questions.
          • Remembering
            • List and describe the Hallmarks of Cancer,

          • Understanding
            • Describe the dynamic relationship between the Hallmarks of Cancer,
              • I would argue that describe the dynamic relationship, engages both an understanding of, and analysis of said dynamic relationship,

          • Applying
            • Explain the stages of Cancer using the state of progression of the Hallmarks of Cancer,
              • Dear Class, in your submissions, consider using the terms: accumulating the Hallmarks of Cancer,

          • Analyzing
            • Illustrate the diversity of the dynamic relationship between Hallmarks in different types of Cancer,

          • Evaluating
            • Can we assess the progress of Cancer by understanding the state of the Hallmarks for a given Cancer type? Dear Class, This is your choice, you can speculate and/or search the literature,

          • Creating
            • Dear Class let us begin to consider Designing Therapies by considering where in the development of Cancer, the transformation of a Normal Cell to a Cancerous Cell, is vulnerable to intervention to reverse that development,
            • Dears, Remember the terms: accumulating the Hallmarks of Cancer,